Gangloff, E*, TS Schwartz,* R Klabacka(GS), A-Y Liu, N Huebschman(UO), AB Bronikowski. In Press. Mitochondria as the central character in a complex narrative: Linking genomics, energetics, and pace-of-life in natural populations of garter snakes. Experimental Gerontology. https://doi.org/10.1016/j.exger.2020.110967
In this article, we show connections among mitochondrial function, organismal metabolism, and genetic variants in long-studied garter snake populations that are either fast- (FA) or slow-aging (SA). At the cellular level, we demonstrate that Fast-aging snakes consume more oxygen relative to Slow-aging snakes; this difference becomes bigger as animals become older. Additionally, we found that genetic variation in the mitochondrial genome (cytochrome-B SNP) is associated with the fast- and slow-aging phenotypes, and the genetic variation predicts metabolic rate in a sex-specific manner.
Gangloff, E, TS Schwartz, R Klabacka, A-Y Liu, N Huebschman, AB Bronikowski. 2020. Mitochondria as the central character in a complex narrative: Linking genomics, energetics, and pace-of-life in natural populations of garter snakes. Experimental Gerontology. https://doi.org/10.1016/j.exger.2020.110967